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Hepatobiliary clearance of labelled mebrofenin in normal and D-galactosamine HCl-induced hepatitis rats and the protective effect of turmeric extract.

Abstract
This study was carried out to see the hepatobiliary clearance of 99m Tc-Mebrofenin radiopharmaceutical in D-galactosamine induced hepatic rats. Furthermore, protective effect of turmeric extract has been studied in these hepatitis rats. Hepatitis was induced with intraperitoneal injection of D-galactosamine (400 mg/kg b. wt) in these rats. 1% turmeric extract was given along with their normal diet for 15 days. Turmeric extract treatment significantly increased the hepatic uptake of radioactivity and accelerated the excretion of 99m Tc-Mebrofenin as compared to control rats. (P < 0.001). In D-galactosamine administered rats, a significant delay was observed in 99m Tc-Mebrofenin excretion as compared to controls. However, D-galactosamine administered rats, pretreated with turmeric extract or concurrently treated with turmeric extract showed a near normal pattern of 99m Tc-Mebrofenin excretion. Hence, it can be suggested that turmeric extract may improve the liver function by detoxification.
AuthorsU R Deshpande, L J Joseph, A M Samuel
JournalIndian journal of physiology and pharmacology (Indian J Physiol Pharmacol) Vol. 47 Issue 3 Pg. 332-6 (Jul 2003) ISSN: 0019-5499 [Print] India
PMID14723320 (Publication Type: Journal Article)
Chemical References
  • Aniline Compounds
  • Imino Acids
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • Galactosamine
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Alkaline Phosphatase
  • technetium Tc 99m mebrofenin
  • Glycine
Topics
  • Alanine Transaminase (blood)
  • Alkaline Phosphatase (metabolism)
  • Aniline Compounds
  • Animals
  • Aspartate Aminotransferases (blood)
  • Bile (metabolism)
  • Chemical and Drug Induced Liver Injury (metabolism, prevention & control)
  • Curcuma (chemistry)
  • Galactosamine
  • Glycine
  • Imino Acids (pharmacokinetics)
  • Injections, Intravenous
  • Liver (enzymology, metabolism)
  • Liver Function Tests
  • Male
  • Organotechnetium Compounds (pharmacokinetics)
  • Phytotherapy
  • Plant Roots (chemistry)
  • Radiopharmaceuticals (pharmacokinetics)
  • Rats
  • Rats, Wistar
  • Tissue Distribution

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