Abstract | BACKGROUND: METHODS: A total of 40 patients with Barrett's esophagus who had undergone a fundoplication were entered into a prospective, randomized, unblinded study comparing argon plasma coagulation with endoscopic surveillance. Treatment was repeated until either no Barrett's epithelium remained or a maximum of 6 treatment sessions. RESULTS: One month after the final treatment, complete ablation was achieved in 12 patients. In the remaining 8, a reduction of over 95% was observed. One patient died at 9 months of an unrelated cause. At 1 year, one patient with residual Barrett's epithelium regressed completely, while relapse of Barrett's esophagus was seen in another because of fundoplication failure. Buried glands were observed in 35% patients at 1 month, but only 5% at 1 year. Dysplasia was never seen. In the surveillance group, partial regression was observed in 11 patients, and, in 3 with short-segment Barrett's esophagus, regression was complete. The length of Barrett's esophagus increased in two patients. Two had low-grade dysplasia initially, but this was not evident at 1 year. Overall, complete ablation was achieved in 12 of 19 (63%) patients in the ablation group and 3 of 20 (15%) in the surveillance group (p<0.01). CONCLUSIONS:
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Authors | Roger Ackroyd, William Tam, Mark Schoeman, Peter G Devitt, David I Watson |
Journal | Gastrointestinal endoscopy
(Gastrointest Endosc)
Vol. 59
Issue 1
Pg. 1-7
(Jan 2004)
ISSN: 0016-5107 [Print] United States |
PMID | 14722539
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adult
- Argon
- Barrett Esophagus
(diagnosis, surgery, therapy)
- Endoscopy, Gastrointestinal
- Esophagus
(pathology)
- Female
- Fundoplication
- Humans
- Laser Coagulation
(methods)
- Male
- Middle Aged
- Prospective Studies
- Treatment Outcome
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