Abstract |
Ca2+ mobilizations in SH-SY5Y and IMR-32 human neuroblastoma cell lines were measured using the fluorescent Ca2+ indicator fura-2. A variety of antagonists ( atropine, pirenzepine, 4-DAMP and N-methyl- scopolamine) inhibited carbamyl choline-induced transient Ca2+ mobilization both in a competitive and a noncompetitive manner. The apparent noncompetitive inhibition constants were lower in IMR-32 than in SH-SY5Y cells even when the competitive inhibition constants were similar. This may relate to the previously reported differential expression of muscarinic receptor subtypes in these cell lines.
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Authors | J Kukkonen, K E Akerman |
Journal | Biochemical and biophysical research communications
(Biochem Biophys Res Commun)
Vol. 189
Issue 2
Pg. 919-24
(Dec 15 1992)
ISSN: 0006-291X [Print] United States |
PMID | 1472064
(Publication Type: Journal Article)
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Chemical References |
- Muscarinic Antagonists
- Parasympatholytics
- Piperidines
- Receptors, Muscarinic
- Scopolamine Derivatives
- Pirenzepine
- Atropine
- 4-diphenylacetoxy-1,1-dimethylpiperidinium
- Calcium
- Fura-2
- N-Methylscopolamine
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Topics |
- Atropine
(pharmacology)
- Calcium
(metabolism)
- Fura-2
- Humans
- Kinetics
- Muscarinic Antagonists
- N-Methylscopolamine
- Neuroblastoma
- Parasympatholytics
(pharmacology)
- Piperidines
(pharmacology)
- Pirenzepine
(pharmacology)
- Receptors, Muscarinic
(drug effects, physiology)
- Scopolamine Derivatives
(metabolism, pharmacology)
- Spectrometry, Fluorescence
- Tumor Cells, Cultured
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