Abstract | OBJECTIVE: METHODS: The morphological and immunological characteristics of 12 cases of GS were studied. FAB classification was made by peripheral blood, bone marrow picture and bone marrow biopsy assay. RESULTS: All of the 12 cases presented with lymphadenopathy and soft tissue mass. Histologically, the tissue infiltration of GS was composed of blastic cells with round to oval nuclei showing an even, pale chromatin pattern. Some with cleaved or notched nuclei. There were prominent nucleoli and scant cytoplasm in the cells and mitosis was easily found. Immunohistochemically, CD(45) and lysozyme were positive in all of the cases, MPO in 11 (92%), CD(68) in 10 (83%), CD(34) in 5 (42%), and TdT in 2 cases (17%). CD(15) and Mac387 were mainly expressed in mature granulocytes. Examination of bone marrow sections and marrow aspirate smears showed that out of the 11 cases tested 8 were AML-M(2), 2 AML-M(1) and 1 AML-M(0). Only 1 case was nonleukemic, ie. solitary granulocytic sarcoma. CONCLUSION:
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Authors | Yan-hui Liu, Heng-guo Zhuang, Xin-bo Liao, Xin-lan Luo, Xiu-ling Cai, Dong-lan Luo |
Journal | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
(Zhonghua Xue Ye Xue Za Zhi)
Vol. 24
Issue 11
Pg. 568-71
(Nov 2003)
ISSN: 0253-2727 [Print] China |
PMID | 14720440
(Publication Type: Journal Article)
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Chemical References |
- Antigens, CD34
- Leukocyte Common Antigens
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Topics |
- Adolescent
- Adult
- Aged
- Antigens, CD34
(analysis)
- Child
- Child, Preschool
- Diagnosis, Differential
- Female
- Humans
- Immunohistochemistry
- Leukocyte Common Antigens
(analysis)
- Male
- Middle Aged
- Sarcoma, Myeloid
(diagnosis, metabolism, pathology)
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