Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis.

Abstract

Idiopathic narcolepsy is associated with deficient hypocretin transmission. Narcoleptic symptoms have recently been described in paraneoplastic encephalitis with anti-Ma2 antibodies. The authors measured CSF hypocretin-1 levels in six patients with anti-Ma2 encephalitis, and screened for anti-Ma antibodies in patients with idiopathic narcolepsy. Anti-Ma autoantibodies were not detected in patients with idiopathic narcolepsy. Four patients with anti-Ma2 encephalitis had excessive daytime sleepiness; hypocretin-1 was not detectable in their cerebrospinal fluid, suggesting an immune-mediated hypocretin dysfunction.

• Authors: S Overeem, J Dalmau, L Bataller, S Nishino, E Mignot, J Verschuuren, G J Lammers
• Journal: Neurology (Neurology) Vol. 62 Issue 1 Pg. 138-40 (Jan 13 2004) ISSN: 1526-632X [Electronic] United States
• PMID: 14718718 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Neoplasm
• Carrier Proteins
• HCRT protein, human
• Intracellular Signaling Peptides and Proteins
• Ma2 antigen
• Nerve Tissue Proteins
• Neuropeptides
• Orexins
• Proteins

Topics

• Adenocarcinoma (immunology)
• Adult
• Aged
• Aged, 80 and over
• Antigens, Neoplasm
• Autoimmune Diseases of the Nervous System (cerebrospinal fluid, complications, immunology)
• Carrier Proteins (cerebrospinal fluid)
• Encephalitis (cerebrospinal fluid, complications, immunology)
• Female
• Humans
• Intracellular Signaling Peptides and Proteins
• Lung Neoplasms (immunology)
• Male
• Middle Aged
• Narcolepsy (complications, immunology)
• Nerve Tissue Proteins
• Neuropeptides (cerebrospinal fluid)
• Orexins
• Ovarian Neoplasms (immunology)
• Paraneoplastic Syndromes, Nervous System (cerebrospinal fluid, complications, immunology)
• Proteins (immunology)
• Testicular Neoplasms (immunology)