Pilot trial of 1-octanol in essential tremor.

Abstract

1-Octanol (an 8-C alcohol currently used as a food-flavoring agent) is known to inhibit tremor in essential tremor (ET) animal models at a much lower dose than ethyl alcohol. The authors conducted a randomized, placebo-controlled pilot trial of a single oral dose of 1 mg/kg of 1-octanol in 12 patients with ET. No significant side effects or signs of intoxication were observed. 1-Octanol significantly decreased tremor amplitude for up to 90 minutes. The results suggest 1-octanol as a well-tolerated and safe potential treatment for ET. Further trials are warranted.

• Authors: K O Bushara, S R Goldstein, G J Grimes Jr, A H Burstein, M Hallett
• Journal: Neurology (Neurology) Vol. 62 Issue 1 Pg. 122-4 (Jan 13 2004) ISSN: 1526-632X [Electronic] United States
• PMID: 14718713 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• 1-Octanol

Topics

• 1-Octanol (adverse effects, therapeutic use)
• Adult
• Aged
• Diagnostic Techniques, Neurological (instrumentation)
• Essential Tremor (diagnosis, drug therapy)
• Female
• Humans
• Male
• Middle Aged
• Pilot Projects
• Safety
• Treatment Outcome