Abstract | OBJECTIVE: METHODS: The authors compared the ability of 29 patients with MD and 5 patients with muscle PFKD to achieve a spontaneous second wind during continuous cycle exercise after an overnight fast. Patients cycled at a constant workload for 15 to 20 minutes (3 MD patients, 3 PFKD patients) and at variable workloads in which peak exercise capacity was determined at 6 to 8 minutes of exercise and again at 25 to 30 minutes of exercise (29 MD patients, 4 PFKD patients). Heart rate was monitored continuously, and perceived exertion (Borg scale) was recorded during each minute of exercise. Oxygen utilization and blood levels of lactate and ammonia were determined at rest and during peak workloads. RESULTS: All variables in both patient groups were similar at 6 to 8 minutes of exercise. Thereafter exercise responses diverged. Each MD patient developed a second wind with a decrease in heart rate and perceived exertion and an increase in work and oxidative capacity. In contrast, no PFKD patient developed a spontaneous second wind. CONCLUSIONS:
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Authors | Ronald G Haller, John Vissing |
Journal | Neurology
(Neurology)
Vol. 62
Issue 1
Pg. 82-6
(Jan 13 2004)
ISSN: 1526-632X [Electronic] United States |
PMID | 14718702
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Ammonia
(blood)
- Child
- Exercise Test
- Fasting
- Female
- Glycogen Storage Disease Type V
(blood, physiopathology)
- Glycogen Storage Disease Type VII
(blood, physiopathology)
- Heart Rate
- Humans
- Lactic Acid
(blood)
- Male
- Middle Aged
- Muscle Fatigue
- Oxidation-Reduction
- Oxygen Consumption
- Physical Exertion
- Pulmonary Gas Exchange
- Recovery of Function
- Time Factors
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