Abstract | BACKGROUND: METHODS: RESULTS: Eighty two percent of prostatectomy specimens demonstrated moderate to strong Apo-D immunoreactivity in areas of HGPIN. In comparison, weak Apo-D immunoreactivity was observed in non-malignant areas in only 24% of specimens. The median (range) percentage cellular area of HGPIN immunopositive for Apo-D (9.7%, 0-42.9), and the cellular concentration of Apo-D (MIOD 3.1, 0-13.3), were intermediate between that of normal (area 0%, 0-53.5%, MIOD 0, 0-12.6) and early stage prostate cancer tissues (area 29.2%, 0-90.8%, MIOD 6.7, 0-28.1). This increase in Apo-D expression from non-malignant, through HGPIN to prostate cancer was statistically significant (P < 0.001), and contrasted with the decrease observed in PSA staining between adjacent areas of normal glands, HGPIN, and cancer (P = 0.026). CONCLUSIONS: The presence of high levels of immunoreactive Apo-D in HGPIN and prostate cancer, but not in non-malignant epithelial cells, is consistent with HGPIN being an intermediate lesion in the transition to prostate cancer, and suggests that cellular Apo-D expression is a marker of malignant transformation of the prostate.
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Authors | R E Hall, D J Horsfall, J Stahl, S Vivekanandan, C Ricciardelli, A M F Stapleton, P T Scardino, P Neufing, Wayne D Tilley |
Journal | The Prostate
(Prostate)
Vol. 58
Issue 2
Pg. 103-8
(Feb 01 2004)
ISSN: 0270-4137 [Print] United States |
PMID | 14716735
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2003 Wiley-Liss, Inc. |
Chemical References |
- Apolipoproteins
- Apolipoproteins D
- Biomarkers, Tumor
- Prostate-Specific Antigen
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Topics |
- Apolipoproteins
(analysis, biosynthesis)
- Apolipoproteins D
- Biomarkers, Tumor
(analysis)
- Cell Transformation, Neoplastic
- Gene Expression Regulation, Neoplastic
- Humans
- Immunoassay
- Male
- Prostate-Specific Antigen
(analysis)
- Prostatectomy
- Prostatic Intraepithelial Neoplasia
(genetics, pathology, surgery)
- Prostatic Neoplasms
(genetics, pathology, surgery)
- Video Recording
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