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Apolipoprotein-D: a novel cellular marker for HGPIN and prostate cancer.

AbstractBACKGROUND:
High grade prostatic intraepithelial neoplasia (HGPIN) is a putative pre-malignant lesion of the prostate. While apolipoprotein-D (Apo-D), an androgen-regulated hydrophobic transporter protein, is expressed in prostate tumors, its expression in HGPIN is unknown.
METHODS:
Immunoreactivity for Apo-D and another androgen-regulated protein, prostate specific antigen (PSA), was investigated in 64 radical prostatectomy tissues by video image analysis.
RESULTS:
Eighty two percent of prostatectomy specimens demonstrated moderate to strong Apo-D immunoreactivity in areas of HGPIN. In comparison, weak Apo-D immunoreactivity was observed in non-malignant areas in only 24% of specimens. The median (range) percentage cellular area of HGPIN immunopositive for Apo-D (9.7%, 0-42.9), and the cellular concentration of Apo-D (MIOD 3.1, 0-13.3), were intermediate between that of normal (area 0%, 0-53.5%, MIOD 0, 0-12.6) and early stage prostate cancer tissues (area 29.2%, 0-90.8%, MIOD 6.7, 0-28.1). This increase in Apo-D expression from non-malignant, through HGPIN to prostate cancer was statistically significant (P < 0.001), and contrasted with the decrease observed in PSA staining between adjacent areas of normal glands, HGPIN, and cancer (P = 0.026).
CONCLUSIONS:
The presence of high levels of immunoreactive Apo-D in HGPIN and prostate cancer, but not in non-malignant epithelial cells, is consistent with HGPIN being an intermediate lesion in the transition to prostate cancer, and suggests that cellular Apo-D expression is a marker of malignant transformation of the prostate.
AuthorsR E Hall, D J Horsfall, J Stahl, S Vivekanandan, C Ricciardelli, A M F Stapleton, P T Scardino, P Neufing, Wayne D Tilley
JournalThe Prostate (Prostate) Vol. 58 Issue 2 Pg. 103-8 (Feb 01 2004) ISSN: 0270-4137 [Print] United States
PMID14716735 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2003 Wiley-Liss, Inc.
Chemical References
  • Apolipoproteins
  • Apolipoproteins D
  • Biomarkers, Tumor
  • Prostate-Specific Antigen
Topics
  • Apolipoproteins (analysis, biosynthesis)
  • Apolipoproteins D
  • Biomarkers, Tumor (analysis)
  • Cell Transformation, Neoplastic
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Immunoassay
  • Male
  • Prostate-Specific Antigen (analysis)
  • Prostatectomy
  • Prostatic Intraepithelial Neoplasia (genetics, pathology, surgery)
  • Prostatic Neoplasms (genetics, pathology, surgery)
  • Video Recording

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