Abstract |
There is much confusion in the literature regarding the differences between Mikulicz disease and Mikulicz syndrome. This may be because there seems to be a connection between the disease and disease processes associated with the syndrome. This article provides historical data discussing the emergence of Mikulicz disease, confusions regarding its definition, and finally offers an explanation to the interrelationships of these two entities. This case report hypothesizes that the non-Hodgkin's lymphoma (NHL), which in association with Sjögren's syndrome and Mikulicz disease in this patient comprised the Mikulicz syndrome, may have transformed into his malignant large-cell gastric lymphoma. It supports conclusions in the literature that Mikulicz disease, benign lymphoepithelial lesion, and Sjögren's syndrome may all be a part of the same disease process as graduated variants of one another, with malignant lymphoma being a recognized complication of these entities.
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Authors | Anastasios A Mihas, Patricia B Lawson, Bernard J Dreiling, V S Gurram, Douglas M Heuman |
Journal | International journal of gastrointestinal cancer
(Int J Gastrointest Cancer)
Vol. 33
Issue 2-3
Pg. 123-7
( 2003)
ISSN: 1537-3649 [Print] United States |
PMID | 14716060
(Publication Type: Case Reports, Journal Article)
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Topics |
- Aged
- Humans
- Lymphoma, B-Cell, Marginal Zone
(pathology)
- Lymphoma, Large B-Cell, Diffuse
(complications)
- Male
- Mikulicz' Disease
(etiology)
- Sjogren's Syndrome
(pathology)
- Stomach Neoplasms
(complications)
- Syndrome
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