[Serum anti-titin antibody in patients with myasthenia gravis].

Abstract

OBJECTIVE:

To study the clinical significance of serum anti-titin antibody level in the diagnosis of myasthenia gravis (MG) with thymoma.

METHOD:

The serum anti-titin antibody was analysed by ELISA method in 40 cases of health control group, 90 cases of MG, 17 cases of MG with thymoma and 7 cases of no-MG thymoma. The positive rate was compared among these groups.

RESULTS:

The positive rate of anti-titin antibody was significantly higher in MG with thymoma patients than MG patients (94% and 3%, P < 0.01). According to the Osserman's classification, anti-titin antibody was present mostly in patients (43%) in IV stage, and also present in 2 cases of 7 who with no-MG thymoma.

CONCLUSION:

Serum anti-titin antibody test is helpful in the diagnosis of MG with thymoma.

• Authors: Yan-feng Li, Jun-bao Zhang, Li-ying Cui
• Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao) Vol. 25 Issue 6 Pg. 725-7 (Dec 2003) ISSN: 1000-503X [Print] China
• PMID: 14714322 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antibodies
• Connectin
• Muscle Proteins
• TTN protein, human
• Protein Kinases

Topics

• Adolescent
• Adult
• Aged
• Antibodies (blood)
• Connectin
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Male
• Middle Aged
• Muscle Proteins (immunology)
• Myasthenia Gravis (complications, diagnosis, immunology)
• Protein Kinases (immunology)
• Thymoma (complications, diagnosis, immunology)
• Thymus Neoplasms (complications, diagnosis, immunology)