An oral B subunit: whole cell vaccine against cholera.

During the last decade there has been a rapid progress in the development of new, much improved vaccines against cholera. These vaccines, which are given orally to stimulate the gut mucosal immune system, are based on either a combination of purified cholera toxin B (binding) subunit and killed cholera vibrios of Inaba and Ogawa serotypes and El Tor and classical biotypes (B subunit-whole cell vaccine, B-WC) or on a live attenuated mutant strain of Vibrio cholerae producing the B subunit (CVD 103-HgR). The safety of the oral B-WC cholera vaccine and the immunogenicity and protective efficacy of this vaccine against both cholera and diarrhoea caused by enterotoxigenic Escherichia coli have been extensively documented, e.g. in a large randomized, placebo-controlled field trial in 90,000 persons living in a cholera endemic area. The potential for inexpensive large-scale manufacturing of the B-WC vaccine has recently been much facilitated by the introduction of recombinant DNA technology for production of the B subunit component. This now gives promise that this vaccine could become a useful, cost-effective tool in future strategies to control cholera both in endemic situations and in relation to acute epidemic outbreaks.
AuthorsJ Holmgren, A M Svennerholm, M Jertborn, J Clemens, D A Sack, R Salenstedt, H Wigzell
JournalVaccine (Vaccine) Vol. 10 Issue 13 Pg. 911-4 ( 1992) ISSN: 0264-410X [Print] ENGLAND
PMID1471411 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Cholera Vaccines
  • Vaccines, Attenuated
  • Vaccines, Inactivated
  • Vaccines, Synthetic
  • Cholera Toxin
  • Administration, Oral
  • Adolescent
  • Adult
  • Bangladesh
  • Child
  • Child, Preschool
  • Cholera (epidemiology, prevention & control)
  • Cholera Toxin (immunology)
  • Cholera Vaccines (administration & dosage, immunology)
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Vaccination
  • Vaccines, Attenuated (immunology)
  • Vaccines, Inactivated (immunology)
  • Vaccines, Synthetic (immunology)
  • Vibrio cholerae (immunology)

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