Prevention of thrombus formation with glyprolines on various models of prethrombotic state and thrombosis in rats.

Abstract

Peroral administration of peptide Pro-Gly-Pro to 10-11-month-old rats with modeled prethrombotic state normalized functions of the anticoagulation system and produced a potent antiplatelet effect. Peroral administration of Pro-Gly peptide before provocation of thrombin generation and thrombus formation prevented death of animals from thrombosis. Experiments on rats with venous thrombosis induced by stasis and administration of thrombin showed that pretreatment with Pro-Gly peptide decreased the weight of formed thrombi.

• Authors: V E Pastorova, L A Lyapina, I P Ashmarin
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 136 Issue 4 Pg. 319-22 (Oct 2003) ISSN: 0007-4888 [Print] United States
• PMID: 14714071 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anticoagulants
• Hemostatics
• Oligopeptides
• Platelet Aggregation Inhibitors
• Thromboplastin

Topics

• Administration, Oral
• Animals
• Animals, Outbred Strains
• Anticoagulants (administration & dosage, chemistry, pharmacology)
• Blood Platelets (drug effects)
• Disease Models, Animal
• Fibrinolysis
• Hemostatics (pharmacology)
• Injections, Intraperitoneal
• Male
• Oligopeptides (administration & dosage, chemistry, pharmacology)
• Platelet Aggregation (drug effects)
• Platelet Aggregation Inhibitors (pharmacology)
• Rats
• Survival Rate
• Thrombophlebitis (blood, drug therapy, pathology)
• Thromboplastin (pharmacology)
• Thrombosis (blood, chemically induced, drug therapy, mortality, pathology, prevention & control)
• Time Factors