HLA-B35-restricted immune responses against survivin in cancer patients.

Abstract	Two HLA-A2 restricted epitopes have recently been identified from the broadly expressed tumor antigen survivin, and several vaccination trials in cancer patients based on these survivin-derived peptides have been initiated. Consequently, there is a crucial need for the identification of survivin epitopes restricted to other HLA-molecules in order to extend the proportion of patients that can enter these ongoing clinical trials. In the present study, we characterized 2 survivin-derived epitopes, which are restricted to HLA-B35. Specific T-cell reactivity against these survivin-derived epitopes was found in the peripheral blood from patients with different B-cell malignancies and melanoma. Substitution of the C-terminal anchor residue of the survivin-derived peptides improved the recognition by tumor-infiltrating lymphocytes from melanoma patients. Furthermore, we demonstrated spontaneous cytotoxic T-cell responses to survivin in a primary melanoma lesion. The characterization of these epitopes allows more patients can be included in the ongoing peptide-based survivin vaccination trials against cancer.
Authors	Sine Reker, Jürgen C Becker, Inge Marie Svane, Elisabeth Ralfkiaer, Per-thor Straten, Mads Hald Andersen
Journal	International journal of cancer (Int J Cancer) Vol. 108 Issue 6 Pg. 937-41 (Mar 01 2004) ISSN: 0020-7136 [Print] United States
PMID	14712500 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	Copyright 2003 Wiley-Liss, Inc.
Chemical References	Antigens, Neoplasm BIRC5 protein, human Epitopes HLA-B35 Antigen Inhibitor of Apoptosis Proteins Microtubule-Associated Proteins Neoplasm Proteins Peptides Survivin
Topics	Alleles Antigens, Neoplasm (immunology) B-Lymphocytes (metabolism) Epitopes Genes, MHC Class I HLA-B35 Antigen (biosynthesis) Humans Immunoenzyme Techniques Immunohistochemistry Immunotherapy Inhibitor of Apoptosis Proteins Lymphocytes, Tumor-Infiltrating (metabolism) Melanoma (therapy) Microtubule-Associated Proteins (chemistry, immunology) Neoplasm Proteins Neoplasms (immunology, metabolism, therapy) Peptides (chemistry) Protein Binding Protein Structure, Tertiary Survivin T-Lymphocytes, Cytotoxic (metabolism)

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