Comparison of the effects of isotonic and hypertonic sodium bicarbonate solutions on acidemic calves experimentally induced by ammonium chloride administration.

Abstract

The objectives of this study were to evaluate and compare the effects of intravenously (IV) administered infusion of isotonic solution (ISB) or hypertonic sodium bicarbonate solution (HSB) on acid-base equilibrium and the plasma osmolarity in acidemic calves experimentally induced by 5 M-NH(4)Cl, IV infusion (1.0 ml/kg, over 1 hr). The ISB and HSB infusion induced progressive and significant increases in their HCO(3)(-) and BE levels that persisted throughout the period of fluid administration. The plasma osmolarity in the ISB groups was significantly decreased. The plasma osmolarity in the HSB group was significantly higher than in the calves in the other groups (p<0.05). ISB solution might be safe and effective for treating and reviving conscious calves from experimentally induced metabolic acidosis.

• Authors: Shigehiro Iwabuchi, Kazuyuki Suzuki, Izumi Abe, Ryuji Asano
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 65 Issue 12 Pg. 1369-71 (Dec 2003) ISSN: 0916-7250 [Print] Japan
• PMID: 14709830 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Hypotonic Solutions
• Isotonic Solutions
• Ammonium Chloride
• Sodium Bicarbonate

Topics

• Acidosis (chemically induced, therapy, veterinary)
• Ammonium Chloride (toxicity)
• Animals
• Cattle
• Cattle Diseases (therapy)
• Hypotonic Solutions
• Infusions, Intravenous
• Isotonic Solutions
• Sodium Bicarbonate (administration & dosage, therapeutic use)