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Approaches to treatment for extraocular retinoblastoma: Children's Hospital Los Angeles experience.

Abstract
Extraocular retinoblastoma is associated with a very poor outcome. At Children's Hospital Los Angeles, 10 of 207 patients with retinoblastoma had extraocular disease. Four patients with no histopathologic risk factors developed extraocular disease. All patients with direct extension into the central nervous system or with distant metastatic disease died. One of three patients with trilateral retinoblastoma and one patient with regional recurrence are alive after autologous bone marrow transplant. Patients with extraocular retinoblastoma who achieve remission may benefit from consolidation of their therapy with autologous bone marrow transplant.
AuthorsRima F Jubran, Anat Erdreich-Epstein, Anna Butturini, A Linn Murphree, Judith G Villablanca
JournalJournal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 26 Issue 1 Pg. 31-4 (Jan 2004) ISSN: 1077-4114 [Print] United States
PMID14707710 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Myeloablative Agonists
Topics
  • Antineoplastic Agents (therapeutic use)
  • Child
  • Child, Preschool
  • Female
  • Head and Neck Neoplasms
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Infant
  • Male
  • Myeloablative Agonists (therapeutic use)
  • Nervous System Neoplasms
  • Retinoblastoma (mortality, pathology, therapy)
  • Retrospective Studies
  • Transplantation, Autologous
  • Treatment Outcome

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