Ventilatory management of acute respiratory distress syndrome: a consensus of two.

Abstract

OBJECTIVE:

To synthesize the emerging body of experimental, observational, and clinical trial data into a practical guideline for safe and effective ventilatory management of acute respiratory distress syndrome.

DATA SOURCES:

Relevant, peer-reviewed, scientific literature and personal observations from clinical practice.

STUDY SELECTION:

Relevant experimental studies and high-impact observational and clinical trials of acute respiratory distress syndrome management.

DATA EXTRACTION:

Detailed review of information contained in published scientific work.

DATA SYNTHESIS:

Interactive discussions between the authors that culminated in our consensus view of appropriate management.

CONCLUSIONS:

Prevention of ventilator-induced lung injury while accomplishing the essential life-supporting roles of mechanical ventilation is a complex undertaking that requires application of principles founded on a broad experimental and clinical database and on the results of well-executed clinical trials. At the bedside, execution of an effective lung-protective ventilation strategy remains an empirical process best guided by integrated physiology and a readiness to revise the management approach depending on the individual's response.

• Authors: John J Marini, Luciano Gattinoni
• Journal: Critical care medicine (Crit Care Med) Vol. 32 Issue 1 Pg. 250-5 (Jan 2004) ISSN: 0090-3493 [Print] United States
• PMID: 14707588 (Publication Type: Journal Article, Review)

Topics

• Animals
• Clinical Trials as Topic
• Disease Models, Animal
• Female
• Humans
• Infant, Newborn
• Male
• Practice Guidelines as Topic
• Prognosis
• Respiration, Artificial (adverse effects, standards)
• Respiratory Distress Syndrome (diagnosis, mortality, therapy)
• Respiratory Distress Syndrome, Newborn (diagnosis, mortality, therapy)
• Risk Assessment
• Survival Rate
• Treatment Outcome