[Application of cyclosporine A in myelodysplastic syndrome--review].

Abstract

Treatment of myelodysplastic syndrome (MDS) remains unsatisfactory. It is possible that immunosuppressive therapy might be effective for a certain subset of patients with MDS. In this review 105 patients with MDS who were treated with cyclosporin A (CsA) including 90 RA, 5 RARS, 10 RAEB, were analyzed. The dose of CsA was 2 - 12 mg/(kg x d) for at least three months. Hematological improvement was observed in 64 patients (61%), and complete remission was observed in 14 patients (13.3%). These results indicated that CsA immunosuppressive therapy may be useful for IPSS low, intermediate-1 and intermediate-2 MDS patients.

• Authors: Mei Guan
• Journal: Zhongguo shi yan xue ye xue za zhi (Zhongguo Shi Yan Xue Ye Xue Za Zhi) Vol. 11 Issue 6 Pg. 678-80 (Dec 2003) ISSN: 1009-2137 [Print] China
• PMID: 14706160 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Immunosuppressive Agents
• Cyclosporine

Topics

• Cyclosporine (adverse effects, therapeutic use)
• Humans
• Immunosuppressive Agents (therapeutic use)
• Myelodysplastic Syndromes (drug therapy, immunology)