All substances are capable of producing toxicity, so nothing is completely non-toxic. Minimally toxic substances are those which produce little toxicity, minor self-limited toxicity, or clinically insignificant effects at most doses. Examples include
silica gel, A&D
ointment,
chalk, lipstick, and non-
camphor lip balms, watercolors, hand dishwashing
detergents, non-
salicylate antacids (excluding
magnesium or
sodium bicarbonate containing products), calamine lotion,
clay, crayons,
diaper rash creams and
ointments,
fabric softeners/sheets, glow products, glue (white, arts, and crafts type), household plant food,
oral contraceptives, pen ink, pencils,
starch/sizing, throat lozenges without
local anesthetics, topical
antibiotics, topical antifungals, topical
steroids, topical
steroids with
antibiotics, and water-based paints. Minimally toxic exposures have the following characteristics: (1) The information specialist has confidence in the accuracy of the history obtained and the ability to communicate effectively with the caller. (2) The information specialist has confidence in the identity of the product(s) or
substance(s) and a reasonable estimation of the maximum amount involved in the exposure. (3) The risks of adverse reactions or expected effects are acceptable to both the information specialist and the caller based on available medical literature and clinical experience. (4) The exposure does not require a healthcare referral since the potential effects are benign and self-limited. However, decisions regarding patient disposition should take into account the patient's intent, symptoms, and social environment. In addition, individual patient circumstances (e.g., pregnancy, pre-existing medical conditions, therapeutic interventions) need to be considered. Minimally toxic exposures may vary in route (dermal, inhalation, ingestion, ocular), chronicity (acute, chronic), and substance composition (single or multi-ingredient, single or multiple product). Future categorization of substances as "minimally toxic" should be based on a process involving review of current knowledge, a thorough analysis of
poisoning experience, and prospective validation.