Hepatitis B virus vaccination of recipients and donors of allogeneic peripheral blood stem cell transplantation.

Abstract

BACKGROUND:

The aim of this study was to determine the role of hepatitis B virus (HBV) vaccination as defined by the seroconversion to hepatitis B surface antibody (anti-HBs) positivity in peripheral blood stem cell transplants.

METHODS:

A total of 65 recipients and their donors were enrolled in this study. Recipients were divided into four distinct groups. Group 1 consisted of individuals who were vaccinated, group 2 consisted of individuals who were naturally immunized, group 3 consisted of individuals who were HBs-Ag positive, and group 4 consisted of individuals who were HBV naïve and not vaccinated.

RESULTS:

Eighty-eight percent of the HBV-vaccinated recipients (14 of 16), who had vaccinated-donors, seroconverted to anti-HBs positivity. Eighty-three percent of HBV-naïve recipients (five of six), who received stem cells from HBV-immune donors, seroconverted to anti-HBs positivity. Two of the four HBs-Ag positive recipients with HBV-immune donors seroconverted to anti-HBs positivity after transplantation. Fifty-seven percent of previously vaccinated-recipients (eight of 14) lost detectable anti-HBs antibody following transplantation. Finally, 31% of HBV-naïve recipients with HBV-naïve donors acquired a de novo HBV infection.

CONCLUSIONS:

(i) Hepatitis B virus immunization of recipients of allogeneic hematopoietic cell transplantation results in an effective antibody response. (ii) The HBV-immune status of the donor plays an important role in post-transplantation HBs-Ab on seroconversion. (iii) Systematic re-immunization of recipients will be necessary to maintain HBV immunity in long-term serving recipients.

• Authors: Ramazan Idilman, Celalettin Ustün, Selim Karayalçin, Aslihan Aktemel, Ahmet R Turkyilmaz, Muhit Ozcan, Onder Arslan, A Mithat Bozdayi, David H Van Thiel, Hamdi Akan
• Journal: Clinical transplantation (Clin Transplant) Vol. 17 Issue 5 Pg. 438-43 (Oct 2003) ISSN: 0902-0063 [Print] Denmark
• PMID: 14703927 (Publication Type: Journal Article)

Chemical References

• Hepatitis B Antibodies
• Hepatitis B Surface Antigens

Topics

• Adolescent
• Adult
• Female
• Hepatitis B (immunology, prevention & control)
• Hepatitis B Antibodies (blood)
• Hepatitis B Surface Antigens (blood)
• Humans
• Immunity, Innate
• Male
• Middle Aged
• Peripheral Blood Stem Cell Transplantation
• Preoperative Care
• Tissue Donors
• Vaccination