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Changes in ultrasonographic appearance of adrenal glands in dogs with pituitary-dependent hyperadrenocorticism treated with trilostane.

Abstract
Trilostane, a 3beta-hydroxysteroid dehydrogenase inhibitor, has been used successfully over the last few years for the treatment of canine pituitary-dependent hyperadrenocorticism. In a prospective study of 19 dogs with pituitary-dependent hyperadrenocorticism, the adrenal glands were measured before and at least 6 months after initiation of trilostane therapy. Right adrenal gland length and caudal pole thickness and left adrenal gland caudal pole thickness increased significantly (p < or = 0.05); there was no significant change in left adrenal gland length. Enlargement of adrenal glands during trilostane therapy may occur as a result of suppression of the negative feedback mechanism affecting cortisol production.
AuthorsPanagiotis Mantis, Christopher R Lamb, Angela L Witt, Reto Neiger
JournalVeterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association (Vet Radiol Ultrasound) 2003 Nov-Dec Vol. 44 Issue 6 Pg. 682-5 ISSN: 1058-8183 [Print] England
PMID14703251 (Publication Type: Evaluation Study, Journal Article)
Chemical References
  • Enzyme Inhibitors
  • Dihydrotestosterone
  • 3-Hydroxysteroid Dehydrogenases
  • trilostane
Topics
  • 3-Hydroxysteroid Dehydrogenases (antagonists & inhibitors)
  • Administration, Oral
  • Adrenal Glands (diagnostic imaging, drug effects)
  • Adrenocortical Hyperfunction (drug therapy, veterinary)
  • Animals
  • Dihydrotestosterone (analogs & derivatives, pharmacology, therapeutic use)
  • Dog Diseases (diagnostic imaging, drug therapy, pathology)
  • Dogs
  • Enzyme Inhibitors (pharmacology, therapeutic use)
  • Female
  • Male
  • Prospective Studies
  • Treatment Outcome
  • Ultrasonography

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