Synthesis and pharmacological evaluation of prenylated and benzylated pterocarpans against snake venom.

Abstract

Edunol (3), a pterocarpan isolated from Harpalyce brasiliana, a plant used in the northeast of Brazil against snakebites, was obtained by synthesis and showed antimyotoxic, antiproteolytic and PLA2 inhibitor properties. These proprieties could be improved through the synthesis of a bioisoster (5), where the prenyl group was replaced by the benzyl group.

• Authors: Alcides J M da Silva, Antonio L Coelho, Alessandro B C Simas, Raphael A M Moraes, Diogo A Pinheiro, Fabrício F A Fernandes, Emerson Z Arruda, Paulo R R Costa, Paulo A Melo
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 14 Issue 2 Pg. 431-5 (Jan 19 2004) ISSN: 0960-894X [Print] England
• PMID: 14698175 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzopyrans
• Crotalid Venoms
• Plant Extracts
• Pterocarpans
• edunol
• Creatine Kinase

Topics

• Animals
• Benzopyrans (chemistry, isolation & purification, pharmacology)
• Bothrops
• Chickens
• Creatine Kinase (metabolism)
• Crotalid Venoms (administration & dosage, antagonists & inhibitors, metabolism)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical (methods)
• In Vitro Techniques
• Injections, Intramuscular
• Mice
• Muscle, Skeletal (enzymology)
• Plant Extracts (chemistry, isolation & purification, pharmacology)
• Plant Roots
• Pterocarpans (chemistry, isolation & purification, pharmacology)