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Significance of rapid turnover proteins in protein-losing gastroenteropathy.

AbstractBACKGROUND/AIMS:
We investigated the significance of rapid turnover proteins (retinal-binding protein, pre-albumin and transferrin) in protein-losing gastroenteropathy.
METHODOLOGY:
We evaluated the levels of these proteins in 12 patients with protein-losing gastroenteropathy.
RESULTS:
The protein-losing gastroenteropathy patients showed very low level of total serum protein of 4.3 +/- 0.7 g/dL, albumin 2.1 +/- 0.4 g/dL, and IgG 682 +/- 232 mg/dL. However, retinal-binding protein was 4.4 +/- 1.9 mg/dL (normal range; 2.5-8.0 mg/dL), pre-albumin 29.3 +/- 7.9 mg/dL (21-43 mg/dL) and transferrin 226 +/- 62 mg/dL (205-370 mg/dL). The levels of rapid turnover proteins, particularly retinal-binding protein and pre-albumin were almost preserved within the normal range, despite hypoproteinemia.
CONCLUSIONS:
If there is a patient with severe hypoproteinemia and preserved levels of rapid turnover proteins, protein-losing gastroenteropathy should be suspected and we get a strong proof to do the following examinations such as a fecal clearance of alpha-1 antitrypsin.
AuthorsHiroaki Takeda, Katsuyoshi Ishihama, Tadahisa Fukui, Shoichiro Fujishima, Tomohiko Orii, Yuichi Nakazawa, Hong-Jin Shu, Sumio Kawata
JournalHepato-gastroenterology (Hepatogastroenterology) 2003 Nov-Dec Vol. 50 Issue 54 Pg. 1963-5 ISSN: 0172-6390 [Print] Greece
PMID14696443 (Publication Type: Journal Article)
Chemical References
  • 11-cis-retinal-binding protein
  • Blood Proteins
  • Carrier Proteins
  • Immunoglobulin G
  • Prealbumin
  • Serum Albumin
  • Transferrin
Topics
  • Adolescent
  • Adult
  • Aged
  • Blood Proteins (metabolism)
  • Carrier Proteins (blood)
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunoglobulin G (blood)
  • Male
  • Middle Aged
  • Prealbumin (metabolism)
  • Protein-Losing Enteropathies (blood, diagnosis)
  • Reference Values
  • Serum Albumin (metabolism)
  • Transferrin (metabolism)

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