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Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells.

Abstract
The aim of this study was to investigate the role of coenzyme Q on the mRNA abundance of PHGPx and the reactive oxygen species (ROS) production in two different cell lines from human prostate, a line of non cancer cells (PNT2) and a line of cancer cells (PC3). Results showed that malignant cells markedly differ in their response to coenzyme Q compared to non-malignant cells, with no changes in PHGPx expression and greater ROS production. Furthermore coenzyme Q supplementation significantly lowered cell growth of the PC3 cancer line without affecting the PNT2. If these results are confirmed with additional experiments, it could represent a novel and interesting approach on the biomedical use of coenzyme Q10 in cancer therapy.
AuthorsJ L Quiles, A J Farquharson, M C Ramírez-Tortosa, I Grant, L Milne, J R Huertas, M Battino, J Mataix, K W J Wahle
JournalBioFactors (Oxford, England) (Biofactors) Vol. 18 Issue 1-4 Pg. 265-70 ( 2003) ISSN: 0951-6433 [Print] Netherlands
PMID14695942 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Free Radicals
  • RNA, Messenger
  • Ubiquinone
  • Glutathione Peroxidase
Topics
  • Cell Line
  • Free Radicals (metabolism)
  • Gene Expression Regulation, Enzymologic (drug effects)
  • Glutathione Peroxidase (genetics)
  • Humans
  • Male
  • Mitochondria (metabolism)
  • Prostate (drug effects, enzymology, ultrastructure)
  • Prostatic Neoplasms (enzymology, pathology)
  • RNA, Messenger (analysis)
  • Tumor Cells, Cultured
  • Ubiquinone (pharmacology)

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