Abstract |
The aim of this study was to investigate the role of coenzyme Q on the mRNA abundance of PHGPx and the reactive oxygen species (ROS) production in two different cell lines from human prostate, a line of non cancer cells (PNT2) and a line of cancer cells (PC3). Results showed that malignant cells markedly differ in their response to coenzyme Q compared to non-malignant cells, with no changes in PHGPx expression and greater ROS production. Furthermore coenzyme Q supplementation significantly lowered cell growth of the PC3 cancer line without affecting the PNT2. If these results are confirmed with additional experiments, it could represent a novel and interesting approach on the biomedical use of coenzyme Q10 in cancer therapy.
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Authors | J L Quiles, A J Farquharson, M C Ramírez-Tortosa, I Grant, L Milne, J R Huertas, M Battino, J Mataix, K W J Wahle |
Journal | BioFactors (Oxford, England)
(Biofactors)
Vol. 18
Issue 1-4
Pg. 265-70
( 2003)
ISSN: 0951-6433 [Print] Netherlands |
PMID | 14695942
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Free Radicals
- RNA, Messenger
- Ubiquinone
- Glutathione Peroxidase
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Topics |
- Cell Line
- Free Radicals
(metabolism)
- Gene Expression Regulation, Enzymologic
(drug effects)
- Glutathione Peroxidase
(genetics)
- Humans
- Male
- Mitochondria
(metabolism)
- Prostate
(drug effects, enzymology, ultrastructure)
- Prostatic Neoplasms
(enzymology, pathology)
- RNA, Messenger
(analysis)
- Tumor Cells, Cultured
- Ubiquinone
(pharmacology)
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