Abstract |
Vaccine-induced hepatitis A antibodies persist up to 10 years in adults, with mathematical models estimating further persistence up to 20-25 years. Thirty-one adults received booster inoculations 12 years after their initial vaccination ( Havrix 720 El.U at months 0, 1, 6). At the time of booster inoculation, all still had detectable antibodies. All but one subject met pre-defined criteria for anamnestic response 14 days after the booster, and all subjects did so after 30 days. The subjects' geometric mean titre (GMT) increased rapidly from 242 IU/L at baseline to 3,832 IU/L at day 14 and 5,282 IU/L at day 30. This study shows a substantial immune response to re-exposure to hepatitis A antigen after 12 years, which occurs rapidly to ensure protection within the average incubation period of hepatitis A virus.
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Authors | Koen Van Herck, Pierre Van Damme, Marc Lievens, Michel Stoffel |
Journal | Journal of medical virology
(J Med Virol)
Vol. 72
Issue 2
Pg. 194-6
(Feb 2004)
ISSN: 0146-6615 [Print] United States |
PMID | 14695659
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2004 Wiley-Liss, Inc. |
Chemical References |
- Hepatitis A Antibodies
- Hepatitis A Vaccines
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Topics |
- Adult
- Female
- Hepatitis A
(prevention & control)
- Hepatitis A Antibodies
(blood)
- Hepatitis A Vaccines
(administration & dosage, immunology)
- Hepatitis A Virus, Human
(immunology)
- Humans
- Immunization
- Immunization, Secondary
- Immunologic Memory
- Male
- Time Factors
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