Transmission-blocking activity of tafenoquine (WR-238605) and artelinic acid against naturally circulating strains of Plasmodium vivax in Thailand.

Abstract

The sporontocidal activity of tafenoquine (WR-238605) and artelinic acid was determined against naturally circulating isolates of Plasmodium vivax in western Thailand. Primaquine was used as a negative control and a dihydroacridine-dione (WR-250547) was used as a positive control. Laboratory-reared Anopheles dirus mosquitoes were infected with P. vivax by allowing mosquitoes to feed on blood (placed in an artificial-membrane feeding apparatus) collected from gametocytemic volunteers reporting to local malaria clinics in Tak province, Thailand. Four days post-infection, mosquitoes were refed on uninfected mice treated 90 minutes earlier with a given drug. Drug activity was determined by assessing oocyst and sporozoite development. Neither primaquine nor artelinic acid affected oocyst or sporozoite development at a dose of 100 mg of base drug/kg of mouse body weight. In contrast, tafenoquine and WR-250547 affected sporogonic development at doses as low as 25.0 and 0.39 mg/kg, respectively. The potential role of these compounds in the prevention of malaria transmission is discussed, as are alternative strategies for the use of transmission-blocking antimalarial drugs.

• Authors: Narong Ponsa, Jetsumon Sattabongkot, Pattamaporn Kittayapong, Nantana Eikarat, Russell E Coleman
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 69 Issue 5 Pg. 542-7 (Nov 2003) ISSN: 0002-9637 [Print] United States
• PMID: 14695093 (Publication Type: Evaluation Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Aminoquinolines
• Antimalarials
• Artemisinins
• Sesquiterpenes
• artelinic acid
• tafenoquine
• Primaquine

Topics

• Aminoquinolines (administration & dosage, pharmacology, therapeutic use)
• Animals
• Anopheles (parasitology)
• Antimalarials (administration & dosage, pharmacology, therapeutic use)
• Artemisinins (administration & dosage, pharmacology, therapeutic use)
• Dose-Response Relationship, Drug
• Humans
• Insect Vectors (parasitology)
• Malaria, Vivax (drug therapy, parasitology)
• Mice
• Parasitic Sensitivity Tests
• Plasmodium vivax (drug effects, growth & development)
• Primaquine (administration & dosage, pharmacology, therapeutic use)
• Sesquiterpenes (administration & dosage, pharmacology, therapeutic use)