[Advances in researches on lactate dehydrogenase-C4 isozyme].

Abstract

Lactate dehydrogenase-C4 isozyme has been widely studied as the sperm-specific antigen in the research of the contraceptive vaccine. Developmental and testis-specific expression of the LDH-C gene requires mechanisms for activation in germ cells and repression in somatic cells. LDH-C promoter, several transcription factors and methylation of CpG dinucleotides have been proved of governing action on LDH-C gene transcription. The strategy is to induce antibodies in the female reproductive tract against LDH-C antigens at a sufficient level to block fertilization. Chemically modified LDH-C4 offers a potential application in the induction of infertility of homologous species in marked contrast to native LDH-C4. In addition, advances are being made in researches on the male contraceptive vaccine and synthetic peptide immunocontraceptive.

• Authors: Yong-Zhong Xiong, Feng-Hua Lan
• Journal: Zhonghua nan ke xue = National journal of andrology (Zhonghua Nan Ke Xue) Vol. 9 Issue 8 Pg. 607-10 (Nov 2003) ISSN: 1009-3591 [Print] China
• PMID: 14689898 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Isoenzymes
• Vaccines, Contraceptive
• L-Lactate Dehydrogenase
• lactate dehydrogenase C4

Topics

• Animals
• Humans
• Isoenzymes (genetics, immunology)
• L-Lactate Dehydrogenase (genetics, immunology)
• Male
• Mice
• Papio
• Rabbits
• Spermatozoa (enzymology)
• Transcription, Genetic
• Vaccines, Contraceptive (immunology)