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5-HT2 serotonin receptor on blood platelet of migraine patients.

Abstract
Several lines of evidence have previously suggested that platelets might play a primary or secondary role in migraine pathogenesis, and that in addition serotonin receptors on human platelets might be involved in those processes. By using [3H]-spiperone as a radioligand and ketanserin to determine the non-specific binding, the numbers of 5-HT2 serotonin receptors on platelet membrane obtained from normal healthy and migraine subjects were determined. We found a significant decrease (p < 0.02) in the maximal receptor numbers (Bmax) on platelet membrane of migraine patients (Bmax = 33.01 +/- 5.57 fmol/mg protein) when compared to the normal healthy group (Bmax = 86.59 +/- 9.09 fmol/mg protein) whereas the dissociation equilibrium constant (Kd) values (2.47 +/- 0.44 nM and 3.41 +/- 0.95 nM for the normal and migraine subjects, respectively) remained unchanged. The platelet response showed a higher degree of aggregability in migraine subjects, whereas the platelet counts were the same. This finding implies that serotonin receptors on the platelet may reflect some aspect of the pathogenesis of migraine headache.
AuthorsP Govitrapong, C Limthavon, A Srikiatkhachorn
JournalHeadache (Headache) Vol. 32 Issue 10 Pg. 480-4 (Nov 1992) ISSN: 0017-8748 [Print] United States
PMID1468904 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Receptors, Serotonin
  • Spiperone
Topics
  • Adult
  • Blood Platelets (metabolism)
  • Electronic Data Processing
  • Female
  • Humans
  • Male
  • Migraine Disorders (blood)
  • Platelet Aggregation
  • Platelet Count
  • Receptors, Serotonin (metabolism)
  • Reference Values
  • Software
  • Spiperone (metabolism)

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