Analysis of glycoconjugates in patients with oral squamous cell carcinoma.

Abstract

BACKGROUND:

Our aim was to examine the levels of glycoconjugates in plasma, erythrocyte membranes and buccal mucosa of healthy subjects and oral cancer patients.

SUBJECTS AND METHODS:

This study was conducted on 48 adult male oral cancer patients with various clinical stages (stage II to stage IV; 16 of each) and 16 disease-free healthy subjects who underwent surgical removal of impacted teeth or vestibuloplasty without inflammation.

RESULTS:

The plasma and tumor tissues glycoconjugates levels were significantly increased, whereas the erythrocyte membranes glycoconjugates were significantly decreased in oral cancer patients as compared to healthy subjects. The levels of glycoconjugates were gradually increased from stage II to stage IV in plasma and tumor tissues and decreased in erythrocyte membranes from stage II to stage IV of oral cancer patients.

CONCLUSION:

The increased plasma glycoconjugates can be due to the expense of erythrocyte membrane glycoconjugates or tumor tissue itself.

• Authors: S Manoharan, M Padmanabhan, K Kolanjiappan, C R Ramachandran, K Suresh
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 339 Issue 1-2 Pg. 91-6 (Jan 2004) ISSN: 0009-8981 [Print] Netherlands
• PMID: 14687898 (Publication Type: Journal Article)

Chemical References

• Glycoconjugates
• Hexosamines
• Hexoses
• N-Acetylneuraminic Acid

Topics

• Adult
• Carcinoma, Squamous Cell (blood, metabolism, pathology)
• Erythrocyte Membrane (metabolism)
• Glycoconjugates (blood, metabolism)
• Hexosamines (blood, metabolism)
• Hexoses (blood, metabolism)
• Humans
• Male
• Middle Aged
• Mouth Mucosa (metabolism)
• Mouth Neoplasms (blood, metabolism, pathology)
• N-Acetylneuraminic Acid (blood, metabolism)
• Neoplasm Staging
• Protein Binding