Abstract | OBJECTIVES: METHODS: This randomized, open-label, comparative five-way crossover study evaluated the 24-h intragastric pH profile of oral esomeprazole 40 mg, lansoprazole 30 mg, omeprazole 20 mg, pantoprazole 40 mg, and rabeprazole 20 mg once daily in 34 Helicobacter pylori-negative patients aged 18-60 yr with symptoms of gastroesophageal reflux disease. Patients were randomly assigned to one of five treatment sequences and study drug was taken on 5 consecutive mornings 30 minutes prior to a standardized breakfast. A washout period of at least 10 days separated each treatment phase. RESULTS: Thirty-four patients provided evaluable data for all five comparators. The mean number of hours of evaluable pH data was > or =23.75 hours. On day 5, intragastric pH was maintained above 4.0 for a mean of 14.0 h with esomeprazole, 12.1 h with rabeprazole, 11.8 h with omeprazole, 11.5 h with lansoprazole, and 10.1 h with pantoprazole (p < or = 0.001 for differences between esomeprazole and all other comparators). Esomeprazole also provided a significantly higher percentage of patients with an intragastric pH greater than 4.0 for more than 12 h relative to the other proton pump inhibitors (p < 0.05). The frequency of adverse events was similar between treatment groups. CONCLUSIONS:
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Authors | Philip Miner Jr, Philip O Katz, Yusong Chen, Mark Sostek |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 98
Issue 12
Pg. 2616-20
(Dec 2003)
ISSN: 0002-9270 [Print] United States |
PMID | 14687806
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Anti-Ulcer Agents
- Benzimidazoles
- Sulfoxides
- Lansoprazole
- Rabeprazole
- Pantoprazole
- Omeprazole
- Esomeprazole
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Topics |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Adolescent
- Adult
- Anti-Ulcer Agents
(therapeutic use)
- Benzimidazoles
(therapeutic use)
- Chi-Square Distribution
- Cross-Over Studies
- Esomeprazole
- Female
- Gastric Acid
(metabolism)
- Gastroesophageal Reflux
(drug therapy)
- Humans
- Hydrogen-Ion Concentration
- Lansoprazole
- Least-Squares Analysis
- Male
- Middle Aged
- Omeprazole
(analogs & derivatives, therapeutic use)
- Pantoprazole
- Rabeprazole
- Sulfoxides
(therapeutic use)
- Treatment Outcome
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