Cortisol metabolism and visceral obesity: role of 11beta-hydroxysteroid dehydrogenase type I enzyme and reduced co-factor NADPH.

Abstract

Several factors including genetic and environmental play a role in the development of obesity and the metabolic syndrome. The transgenic mouse overexpressing 11beta-hydroxysteroid dehydrogenase (11beta-HSD) develops visceral obesity. However, it remains unclear how a ubiquitously expressed 11beta-HSD1 enzyme affects adipose tissue so much that it would lead to obesity. In this commentary we explore the possibility that increased intracellular availability of reduced co-factor, NADPH, could exacerbate the enzymatic activity.

• Authors: Anil K Agarwal
• Journal: Endocrine research (Endocr Res) Vol. 29 Issue 4 Pg. 411-8 (Nov 2003) ISSN: 0743-5800 [Print] England
• PMID: 14682470 (Publication Type: Journal Article, Review)

Chemical References

• NADP
• 11-beta-Hydroxysteroid Dehydrogenases
• Cortisone Reductase
• Hydrocortisone

Topics

• 11-beta-Hydroxysteroid Dehydrogenases (metabolism)
• Animals
• Cortisone Reductase (deficiency)
• Humans
• Hydrocortisone (metabolism)
• NADP (metabolism)
• Obesity (enzymology, metabolism)
• Pentose Phosphate Pathway