[Antihypertensive treatment with eprosartan mesilate of patients in acute and late periods of ischemic stroke].

Abstract	Twenty patients with stroke of hemisphere localization developed as a result of arterial hypertension were treated with eprosartan mesilat. An estimation of the drug efficacy was conducted in comparison with other hypotensive medicines (control group). Eprosartan was used in dosage 600 mg daily. The study was carried out during 12 months, along with a monitoring of the most relevant hemodynamic indices, evaluation of somatic and neurological state of the patients as well as of some neuropsychological functions and quality of life, statistical significance of the results being determined. Pronounced hypotensive effect of the drug was found both in acute and late periods of stroke. Eprosartan mesilat monotherapy was effective in 75% of the patients. The most important feature proved to be a decrease of arterial pressure variability from the first days of the treatment, less frequency of secondary strokes being detected as well.
Authors	E I Gusev, M Iu Martynov, A N Boĭko, E B Petukhov, A N Makarov
Journal	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 103 Issue 11 Pg. 15-20 ( 2003) ISSN: 1997-7298 [Print] Russia (Federation)
Vernacular Title	Gipotenzivnaia terapiia mezilatom éprosartana v ostrom i otdalennom periodakh ishemicheskogo insul'ta.
PMID	14681960 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)
Chemical References	Acrylates Angiotensin II Type 1 Receptor Blockers Antihypertensive Agents Imidazoles Thiophenes eprosartan
Topics	Acrylates (administration & dosage, therapeutic use) Acute Disease Aged Angiotensin II Type 1 Receptor Blockers Antihypertensive Agents (administration & dosage, therapeutic use) Chi-Square Distribution Data Interpretation, Statistical Diastole Female Hemodynamics Humans Hypertension (complications, drug therapy, physiopathology) Imidazoles (administration & dosage, therapeutic use) Male Middle Aged Quality of Life Recurrence Stroke (drug therapy, etiology) Systole Thiophenes Time Factors

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