Neuroblastoma: management, recurrence, and follow-up.

The clinical use of N-myc amplification in neuroblastoma management has served as a paradigm for "bench to bedside" medicine. It is hoped that the quest for molecular markers such as neurotrophin, TrkA, and TrkB will continue to advance the understanding of neuroblastoma. In addition, animal models of neuroblastoma (N-myc transgenic mice, and neuroblastoma xenografts) have been established to assess the efficacy of novel treatments. These advances are likely to improve clinical practice in the future.
AuthorsKeith L Lee, Jian F Ma, Linda D Shortliffe
JournalThe Urologic clinics of North America (Urol Clin North Am) Vol. 30 Issue 4 Pg. 881-90 (Nov 2003) ISSN: 0094-0143 [Print] United States
PMID14680322 (Publication Type: Journal Article, Review)
  • Animals
  • Child
  • Child, Preschool
  • Humans
  • Infant
  • Mice
  • Mice, Transgenic
  • Neoplasm Staging
  • Neuroblastoma (diagnosis, pathology, therapy)

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