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Tumbling down a different pathway to genetic instability.

Abstract
Ulcerative colitis (UC), a chronic inflammatory condition associated with a predisposition to colon cancer, is frequently characterized by DNA damage in the form of microsatellite instability (MSI). A new report links inflammation in UC with increases in the DNA repair enzymes 3-methyladenine DNA glycosylase and apurinic/apyrimidinic endonuclease, and, paradoxically, with increased MSI. These findings may represent a novel mechanism contributing to MSI in chronic inflammation.
AuthorsHaiwei H Guo, Lawrence A Loeb
JournalThe Journal of clinical investigation (J Clin Invest) Vol. 112 Issue 12 Pg. 1793-5 (Dec 2003) ISSN: 0021-9738 [Print] United States
PMID14679175 (Publication Type: Comment, Journal Article, Review)
Chemical References
  • 3-methyladenine-DNA glycosylase
  • DNA Glycosylases
  • DNA-(Apurinic or Apyrimidinic Site) Lyase
Topics
  • Base Sequence
  • Colitis, Ulcerative (genetics)
  • DNA Damage
  • DNA Glycosylases (metabolism)
  • DNA Repair
  • DNA Sequence, Unstable
  • DNA-(Apurinic or Apyrimidinic Site) Lyase (metabolism)
  • Humans
  • Inflammation
  • Microsatellite Repeats
  • Models, Biological
  • Molecular Sequence Data
  • Mutation

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