Abstract |
1. Intraplantar injection of carrageenin into the mouse hind paw produced hyperalgesia when measured by the paw pressure test (Randall & Selitto method). 2. Subcutaneous administration of L-arginine (100-1,000 mg kg-1), a possible precursor of kyotorphin which is an endogenous analgesic neuropeptide, inhibited carrageenin-induced hyperalgesia in a dose-dependent manner. This effect was blocked by subcutaneous administration of naloxone, naltrindole, a selective delta-opioid receptor antagonist ( enkephalin antagonist), and D- arginine. 3. Intracerebroventricular administration of L-leucyl-L-arginine inhibited the antinociceptive effect of systemically administered L-arginine in hyperalgesic mice. 4. Intracerebroventricular administration of L-arginine (3 and 30 micrograms per mouse) and kyotorphin (300 ng-3 micrograms per mouse) produced antinociception in hyperalgesic mice. The antinociceptive effects of L-arginine but not kyotorphin were blocked by intracerebroventricular administration of D- arginine. 5. These results suggest that L-arginine-induced antinociception is mediated by activation of 'kyotorphinergic' nerves followed by activation of the 'opioidergic' (possible 'enkephalinergic') nerves in the central nervous system.
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Authors | A Kawabata, Y Nishimura, H Takagi |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 107
Issue 4
Pg. 1096-101
(Dec 1992)
ISSN: 0007-1188 [Print] England |
PMID | 1467831
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics
- Dipeptides
- Endorphins
- Indoles
- Morphinans
- Narcotic Antagonists
- kyotorphin
- leucylarginine
- Naltrexone
- Carrageenan
- Arginine
- naltrindole
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Topics |
- Analgesics
(antagonists & inhibitors, pharmacology)
- Animals
- Arginine
(administration & dosage, antagonists & inhibitors, pharmacology)
- Brain
(drug effects)
- Carrageenan
- Dipeptides
(pharmacology)
- Endorphins
(administration & dosage, pharmacology)
- Hyperalgesia
(chemically induced, physiopathology)
- Indoles
(pharmacology)
- Injections, Subcutaneous
- Male
- Mice
- Morphinans
(pharmacology)
- Naltrexone
(analogs & derivatives)
- Narcotic Antagonists
(pharmacology)
- Pain Measurement
- Stereoisomerism
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