Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: SUMMARY: The discovery of the FIP1L1-PDGFRA fusion gene in the hypereosinophilic syndrome is an example of the power of clinical translational research and identifies interstitial chromosomal deletion as a novel mechanism to generate oncogenic tyrosine kinase fusion genes.
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Authors | Jan Cools, Elizabeth H Stover, Iwona Wlodarska, Peter Marynen, D Gary Gilliland |
Journal | Current opinion in hematology
(Curr Opin Hematol)
Vol. 11
Issue 1
Pg. 51-7
(Jan 2004)
ISSN: 1065-6251 [Print] United States |
PMID | 14676627
(Publication Type: Journal Article, Review)
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Chemical References |
- Oncogene Proteins, Fusion
- Recombinant Fusion Proteins
- mRNA Cleavage and Polyadenylation Factors
- FIP1L1-PDGFRA fusion protein, human
- Receptor, Platelet-Derived Growth Factor alpha
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Topics |
- Amino Acid Sequence
- Humans
- Hypereosinophilic Syndrome
(diagnosis, enzymology, genetics)
- Male
- Molecular Sequence Data
- Oncogene Proteins, Fusion
- Receptor, Platelet-Derived Growth Factor alpha
(genetics, physiology)
- Recombinant Fusion Proteins
(metabolism)
- Sequence Deletion
- mRNA Cleavage and Polyadenylation Factors
(genetics, physiology)
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