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Medical management of first trimester incomplete miscarriage using misoprostol.

Abstract
This prospective study looked at the effectiveness of 400 microg oral misoprostol in the management of women with a first trimester incomplete miscarriage with retained products of conception measuring between 15 mm and 50 mm on transvaginal ultrasound scan. Of 164 eligible women, 131 agreed to participate. Successful treatment, defined as an empty uterus on scan after 10 days with no bleeding, was achieved in 77.7% of women. Some women with retained products opted to have further misoprostol or conservative management instead of surgical evacuation and in total 92.4% of women completed their miscarriage without requiring surgery. Most bleeding was mild (31.3%) to moderate (38.9%), lasting on average 6.4 days. Forty-five per cent of women needed no pain relief, 51% received oral analgesia and 4% intramuscular opiates. Adverse effects included nausea (10.93%), diarrhoea (2.34%), vomiting (7.8%) and hypotension (4.68%). There were no infections. We concluded that a single dose of 400 microg of oral misoprostol was an effective treatment for women presenting with an incomplete miscarriage.
AuthorsL B Coughlin, D Roberts, N G Haddad, A Long
JournalJournal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology (J Obstet Gynaecol) Vol. 24 Issue 1 Pg. 67-8 (Jan 2004) ISSN: 0144-3615 [Print] England
PMID14675985 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Abortifacient Agents, Nonsteroidal
  • Misoprostol
Topics
  • Abortifacient Agents, Nonsteroidal (administration & dosage, adverse effects)
  • Abortion, Incomplete (diagnostic imaging, drug therapy)
  • Administration, Oral
  • Adolescent
  • Adult
  • Endosonography
  • Female
  • Follow-Up Studies
  • Humans
  • Maternal Age
  • Misoprostol (administration & dosage, adverse effects)
  • Pregnancy
  • Pregnancy Trimester, First
  • Pregnancy, High-Risk
  • Prospective Studies
  • Risk Assessment
  • Treatment Outcome

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