[Pulmonary rhabdomyosarcoma generated during treatment of testicular tumor].

Abstract

A 23-year-old male was admitted to our hospital for the management of pulmonary metastases. He had undergone right high orchiectomy, chemotherapy with four courses of PEB regimen (cisplatin, etoposide, bleomycin) and retroperitoneal lymph node dissection the previous year. The pathological findings showed mixed germ cell tumor (seminoma, yolk sac tumor, embryonal carcinoma) in the testis and mature teratoma in the draining lymph node. Two courses of salvage chemotherapy using a VIP regimen (etoposide, ifosfamide, cisplatin) were performed after diagnosis of pulmonary metastases, but had no affect on tumor size. Video-assisted excision of pulmonary metastases was then performed, giving a pathological diagnosis of rhabdomyosarcoma in all three resected tumors. The operation was followed by three courses of CYVADIC (cyclophosphamide, vincristine, adriamycin, dacarbazin) chemotherapy and oral cyclophosphamide, as a small residual tumor was suspected. These chemotherapeutic interventions have appeared effective, with no apparent recurrence of lesions at present, one year after the excision of pulmonary metastases.

• Authors: Masafumi Kita, Yutaka Sasaki, Mitsuhiko Okuyama, Yuji Saga, Hiroshi Hashimoto, Shigeo Kaneko, Sunao Yachiku, Masayuki Tokumitsu, Fumiei Inada, Hironori Ishida
• Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology (Nihon Hinyokika Gakkai Zasshi) Vol. 94 Issue 7 Pg. 696-700 (Nov 2003) ISSN: 0021-5287 [Print] Japan
• PMID: 14672002 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• Vincristine
• Etoposide
• Dacarbazine
• Doxorubicin
• Cyclophosphamide
• Cisplatin
• Ifosfamide

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Carcinoma, Embryonal (pathology, therapy)
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Cyclophosphamide (administration & dosage)
• Dacarbazine (administration & dosage)
• Doxorubicin (administration & dosage)
• Drug Administration Schedule
• Endodermal Sinus Tumor (pathology, therapy)
• Etoposide (administration & dosage)
• Humans
• Ifosfamide (administration & dosage)
• Lung Neoplasms (secondary, therapy)
• Lymph Node Excision
• Male
• Orchiectomy
• Pneumonectomy
• Rhabdomyosarcoma (secondary, therapy)
• Seminoma (pathology, therapy)
• Testicular Neoplasms (therapy)
• Vincristine (administration & dosage)