Abstract |
DA-8159 is a pyrazolopyrimidinone derivative which exhibits potent and selective phosphodiesterase type 5 (PDE5) inhibition. The aim of this study was to investigate the effects of DA-8159 on inducing a penile erection in rabbits with an acute spinal cord injury (ASCI). DA-8159 was given either orally (1, 3, or 10 mg/kg) or intravenously (0.1 or 0.3 mg/kg) to conscious male albino rabbits with a surgical transection of the spinal cord at the L2-L4 lumbar vertebra or ischemic-reperfusion SCI rabbits. Erection was evaluated in a time-course manner by measuring the length of the uncovered penile mucosa. DA-8159 induced a dose-dependent erection in both transection and ischemic-reperfusion ASCI rabbits. The efficacy of DA-8159 was potentiated by an intravenous injection of sodium nitroprusside, a nitric oxide donor. Potentiation of the effect by nitric oxide donor implies that DA-8159 can enhance the erectile activity during sexual arousal. These results suggest that DA-8159 may be useful for treating erectile dysfunction in patients with an SCI.
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Authors | B O Ahn, K K Kang, G J Ahn, J W Kwon, W B Kim, K-S Kang, Y-S Lee |
Journal | International journal of impotence research
(Int J Impot Res)
Vol. 15
Issue 6
Pg. 405-11
(Dec 2003)
ISSN: 0955-9930 [Print] England |
PMID | 14671658
(Publication Type: Journal Article)
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Chemical References |
- Pyrimidines
- Sulfonamides
- 3',5'-Cyclic-GMP Phosphodiesterases
- Cyclic Nucleotide Phosphodiesterases, Type 5
- udenafil
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Topics |
- 3',5'-Cyclic-GMP Phosphodiesterases
(antagonists & inhibitors)
- Acute Disease
- Animals
- Area Under Curve
- Cyclic Nucleotide Phosphodiesterases, Type 5
- Disease Models, Animal
- Erectile Dysfunction
(drug therapy, etiology)
- Male
- Penile Erection
(drug effects, physiology)
- Pyrimidines
(pharmacology)
- Rabbits
- Reperfusion Injury
(drug therapy)
- Spinal Cord
(pathology)
- Spinal Cord Injuries
(complications, pathology)
- Sulfonamides
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