A monozygotic conjoined twin pregnancy discordant for laterality of cleft lip.

Abstract

Conjoined twins discordant for phenotype of cleft lip are reported. One had right-sided cleft lip, while the co-twin had left-sided cleft lip. Both twins had a normal 46,XY karyotype. Genotyping at 50 polymorphic loci revealed that the twins were identical (monozygotic). Our analysis suggests that the laterality of cleft lip is more affected by the process of twinning than by genetic factors.

• Authors: Hideaki Masuzaki, Kiyonori Miura, Ko-ichiro Yoshiura, Shuichiro Yoshimura, Tadayuki Ishimaru
• Journal: Gynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 57 Issue 2 Pg. 100-2 ( 2004) ISSN: 0378-7346 [Print] Switzerland
• PMID: 14671419 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2004 S. Karger AG, Basel

Topics

• Adult
• Cleft Lip (etiology, genetics, pathology)
• Diseases in Twins (etiology, genetics)
• Female
• Humans
• Pregnancy
• Twinning, Monozygotic (physiology)
• Twins, Conjoined (embryology, pathology)
• Twins, Monozygotic