Prevention of HIV-2 and SIVSM infection in cynomolgus monkeys by active or passive immunization.

Abstract

We have established experimental infection with HIV-2 and SIVsm in cynomolgus monkeys and successfully used these models for vaccine experiments. Protection against homologous HIV-2 infection was demonstrated in two of two monkeys immunized with a Triton-X100-treated whole HIV-2SBL-6669 vaccine in incomplete Freund's adjuvant and in 2 of 4 monkeys immunized with a formalin-inactivated whole HIV-2 vaccine in RIBI adjuvant. Monkeys preinfected with a live poorly replicating HIV-2 strain were shown to develop cross-protection against SIV-induced disease. We have shown also that HIV-2 and SIVsm infection in cynomolgus monkeys can be prevented by passive immunization. These results raise hope for effective immunization against HIV infections in humans.

• Authors: G Biberfield, P Putkonen, R Thorstensson, E Norrby
• Journal: AIDS research and human retroviruses (AIDS Res Hum Retroviruses) Vol. 8 Issue 8 Pg. 1511-3 (Aug 1992) ISSN: 0889-2229 [Print] United States
• PMID: 1466992 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• AIDS Vaccines
• Antibodies, Viral
• HIV Antibodies
• Viral Vaccines

Topics

• AIDS Vaccines (immunology)
• Animals
• Antibodies, Viral (biosynthesis, immunology)
• Cross Reactions
• HIV Antibodies (biosynthesis, immunology)
• HIV Infections (prevention & control)
• HIV-2 (immunology)
• Immunization, Passive
• Macaca fascicularis (immunology)
• Simian Acquired Immunodeficiency Syndrome (prevention & control)
• Simian Immunodeficiency Virus (immunology)
• Vaccination
• Viral Vaccines (immunology)