| Abstract | Although T-prolymphocytic leukemia (T-PLL) is characterized by organ infiltration, small-intestinal involvement is rare. We performed an unrelated allogeneic bone marrow transplantation in a patient with T-PLL who had multiple lymphomatous polyposis of the small intestine refractory to combination chemotherapy (cyclophosphamide, vincristine, and prednisolone [COP] and fludarabine plus cyclophosphamide). The patient developed no graft-versus-host disease (GVHD) and remains in complete remission 16 months after the transplantation. T-PLL is usually refractory to chemotherapy and is a T-cell malignancy with poor prognosis. There have been several reports on allogeneic hematopoietic stem-cell transplantation (allo-HSCT) for T-PLL, but none on allo-HSCT for T-PLL patients with intestinal involvement. It is suggested that allo-HSCT may improve the prognosis in patients with T-PLL involving the small intestine. |
| Authors | Kazuyuki Murase, Takuya Matsunaga, Tsutomu Sato, Kageaki Kuribayashi, Katsuhisa Kogawa, Yutaka Kawano, Tetsuro Okamoto, Tetsuji Takayama, Hideki Watanabe, Yoshiro Niitsu, Yasuo Hirayama
(Affiliation: Fourth Department of Internal Medicine, Sapporo Medical University, S1W17, Chuo-ku, Sapporo 060-8543, Japan.)
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| Journal | International journal of clinical oncology / Japan Society of Clinical Oncology
(Int J Clin Oncol)
Vol. 8
Issue 6
Pg. 391-4
(Dec 2003)
ISSN: 1341-9625 Japan |
| PMID | 14663643
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- COP protocol 2
- fludarabine
- Cyclophosphamide
- Prednisone
- Vidarabine
- Vincristine
|
| Topics |
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, therapeutic use)
- Bone Marrow Transplantation
- Cyclophosphamide
(administration & dosage)
- Drug Resistance, Neoplasm
- Humans
- Intestinal Polyposis
(etiology, pathology)
- Leukemia, Prolymphocytic
(complications, therapy)
- Leukemia, T-Cell
(complications, therapy)
- Male
- Prednisone
(administration & dosage)
- Transplantation, Homologous
- Treatment Outcome
- Vidarabine
(administration & dosage, analogs & derivatives)
- Vincristine
(administration & dosage)
|
