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3-OH-pip-BTCP, a metabolite of the potent DA uptake blocker BTCP, exerts cocaine-like action in rats.

Abstract
A previous study showed that N-[1-(2-benzo[b]thiophenyl)cyclohexyl]piperidin-3-ol (3-OH-pip-BTCP), an active metabolite of the potent dopamine reuptake inhibitor N-[1-(2-benzo[b]thiophenyl)cyclohexyl]piperidine (BTCP), exhibits stimulant effects in rats (i.e. increases dopamine levels in the nucleus accumbens and increases locomotion). The present study sought to further characterize the behavioral profile of 3-OH-pip-BTCP, specifically, its interaction with cocaine-maintained behavior. Cocaine self-administration was examined in 3-OH-pip-BTCP pretreated rats. 3-OH-pip-BTCP (0-20 mg/kg, i.p.) dose-dependently decreased cocaine self-administration. Additionally, 3-OH-pip-BTCP (10 mg/kg) shifted the cocaine dose-response to the left. Together, these results suggest that 3-OH-pip-BTCP shares similar reinforcing effects with cocaine and therefore may serve as a substitutive drug and possible agonist therapy for cocaine addiction.
AuthorsRémi Martin-Fardon, Christina U Lorentz, Jean-Marc Kamenka, Friedbert Weiss
JournalNeuroreport (Neuroreport) Vol. 14 Issue 18 Pg. 2439-44 (Dec 19 2003) ISSN: 0959-4965 [Print] England
PMID14663207 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Dopamine Uptake Inhibitors
  • N-(1-(2-benzo(b)thiophenyl)cyclohexyl)piperidin-3-ol
  • 1-(1-(2-benzo(b)thienyl)cyclohexyl)piperidine
  • Cocaine
  • Phencyclidine
Topics
  • Animals
  • Cocaine (antagonists & inhibitors, pharmacology)
  • Dopamine Uptake Inhibitors (metabolism, pharmacology)
  • Dose-Response Relationship, Drug
  • Male
  • Phencyclidine (analogs & derivatives, metabolism, pharmacology)
  • Rats
  • Rats, Wistar
  • Self Administration

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