Isolation, structure elucidation and biological activities of trichofumins A, B, C and D, new 11 and 13mer peptaibols from Trichoderma sp. HKI 0276W.

Abstract

Trichofumins A-D were isolated from cultures of Trichoderma sp. HKI 0276 as new 11 and 13mer peptaibols. Similar to 15mer peptaibols they promote morphogenesis of the fungus Phoma destructiva and cause hypothermia in mice as a characteristic of neuroleptic activity. Membrane measurements using a synthetic BLM model showed that A, B, C and D increased membrane permeability for cations in a similar manner as was shown for larger peptaibols but with comparably lower efficiency.

• Authors: Albrecht Berg, Pavel A Grigoriev, Thomas Degenkolb, Torsten Neuhof, Albert Härtl, Brigitte Schlegel, Udo Gräfe
• Journal: Journal of peptide science : an official publication of the European Peptide Society (J Pept Sci) 2003 Nov-Dec Vol. 9 Issue 11-12 Pg. 810-6 ISSN: 1075-2617 [Print] England
• PMID: 14658800 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fungal Proteins
• Ionophores
• Lipid Bilayers

Topics

• Animals
• Cell Membrane Permeability (drug effects)
• Electrophysiology
• Fungal Proteins (chemistry, isolation & purification, pharmacology)
• Hypothermia (chemically induced)
• Ionophores (chemistry, isolation & purification, pharmacology)
• Lipid Bilayers
• Male
• Mice
• Morphogenesis (drug effects)
• Trichoderma (chemistry)