Abstract | OBJECTIVE: METHODS AND RESULTS: Participants were from an occupational cohort of 573 middle-aged women and men who were free of symptomatic cardiovascular disease at baseline. Ultrasound examination of the common carotid arteries, lipid level determination, and risk factor assessment were performed at baseline and 18-month follow-up. Plasma levels of antioxidants were determined at baseline only. Change in IMT was related to baseline plasma antioxidant levels in regression models controlling for covariates. In models adjusted for age, sex, and smoking status, 18-month change in IMT was significantly inversely related to the 3 measured oxygenated carotenoids ( lutein, beta-cryptoxanthin, zeaxanthin; P<0.02 for all) and one hydrocarbon carotenoid, alpha-carotene (P=0.003). After adjusting for additional cardiac risk factors and potential confounders, including high-sensitivity C-reactive protein, these associations remained significant (P<0.05). CONCLUSIONS:
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Authors | James H Dwyer, Maura J Paul-Labrador, Jing Fan, Anne M Shircore, C Noel Bairey Merz, Kathleen M Dwyer |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 24
Issue 2
Pg. 313-9
(Feb 2004)
ISSN: 1524-4636 [Electronic] United States |
PMID | 14656738
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antioxidants
- Lipoproteins
- Xanthophylls
- Zeaxanthins
- beta Carotene
- Vitamin A
- Carotenoids
- alpha-carotene
- Lycopene
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Topics |
- Adult
- Age Factors
- Antioxidants
(metabolism)
- Arteriosclerosis
(blood, epidemiology, prevention & control)
- Carotenoids
(adverse effects, blood, pharmacology, therapeutic use)
- Carotid Artery, Common
(drug effects, pathology)
- Fasting
(blood)
- Female
- Follow-Up Studies
- Humans
- Lipoproteins
(blood)
- Los Angeles
- Lycopene
- Male
- Middle Aged
- Predictive Value of Tests
- Prospective Studies
- Regression Analysis
- Sex Factors
- Smoking
(blood, epidemiology)
- Surveys and Questionnaires
- Tunica Intima
(drug effects, pathology)
- Tunica Media
(drug effects, pathology)
- Vitamin A
(adverse effects, pharmacology, therapeutic use)
- Xanthophylls
- Zeaxanthins
- beta Carotene
(adverse effects, analogs & derivatives, blood, pharmacology, therapeutic use)
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