[Cyclosporine in the treatment of glomerular diseases in children].

From June 1987 to June 1991 at the Belgrade University Children's Hospital 10 patients, 5 males and 4 females, aged 2-16 years, with chronic glomerular disease, were treated with CyA. Seven patients had INS, 2 lupus nephritis and one IgA nephritis. Before initiation of CyA, all but one, were treated with classic immunosuppressive therapy, which had no effect (8/10) and/or had serious adverse effects (9/10). CyA dosage was initiated at 4-6 mg/kg/BW, and was subsequently adjusted to achieve CyA concentrations in blood at range 50-100 ng/ml. Treatment duration was 2-17 months. Patient compliance to CyA therapy was observed in 5/7 INSs: 2 cortico-sensitive (1 with FSGS was cortico-dependent and 1 had frequent relapses) and 3 cortico-resistant patients (2 with FSGS and 1 with minimal histologic changes). After drug withdrawal, only one of the patients who responded, had no relapse. One of the two patients with SLE showed improvement during CyA administration, while no response was observed in the patient with IgA nephritis. Adverse experiences with CyA therapy involved decreased renal function (2/10), arterial hypertension (1/10), hyperbilirubinaemia (1/10), transient LDH increase and hyperuricaemia (1/10).
AuthorsA Peco-Antić, M Popović-Rolović, O Jovanović, M Kostić, D Popović
JournalSrpski arhiv za celokupno lekarstvo (Srp Arh Celok Lek) 1992 Mar-Apr Vol. 120 Issue 3-4 Pg. 132-6 ISSN: 0370-8179 [Print] YUGOSLAVIA
Vernacular TitleCiklosporin u lecenju glomerulskih bolesti kod dece.
PMID1465661 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Cyclosporine
  • Adolescent
  • Child
  • Child, Preschool
  • Cyclosporine (therapeutic use)
  • Female
  • Glomerulonephritis (drug therapy)
  • Humans
  • Infant
  • Male
  • Nephrotic Syndrome (drug therapy)

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