Xylitol 5-P formation by dental plaque after 12 weeks' exposure to a xylitol/sorbitol containing chewing gum.

Abstract

Five subjects used xylitol-containing chewing gum for 12 wk. Dental plaque was collected before and after the exposure to xylitol. The plaque samples were examined for their capacity to form xylitol 5-P by incubation with 14C labeled xylitol, extraction and separation on HPLC. It was found that the capacity of the plaque to form xylitol 5-P was not reduced during the xylitol exposure in any of the subjects. No other xylitol-derived metabolites were observed. The inhibitory capacity of xylitol thus appears to be maintained after 12 wk exposure to xylitol.

• Authors: S M Wåler, S Assev, G Rölla
• Journal: Scandinavian journal of dental research (Scand J Dent Res) Vol. 100 Issue 6 Pg. 319-21 (Dec 1992) ISSN: 0029-845X [Print] Denmark
• PMID: 1465564 (Publication Type: Journal Article)

Chemical References

• Acetates
• Carbon Radioisotopes
• Chewing Gum
• Formates
• Lactates
• Pentosephosphates
• Sorbitol
• xylitol 5-phosphate
• Xylitol

Topics

• Acetates (metabolism)
• Adult
• Carbon Radioisotopes
• Chewing Gum
• Chromatography, High Pressure Liquid
• Dental Plaque (chemistry, metabolism)
• Formates (metabolism)
• Humans
• Lactates (metabolism)
• Pentosephosphates (analysis, metabolism)
• Sorbitol (administration & dosage)
• Xylitol (administration & dosage, metabolism)