Abstract | BACKGROUND/AIMS: METHODS: Seventeen patients with acetaminophen-induced fulminant hepatic failure between January 1996 and December 2001 were retrospectively studied. A liver dialysis unit became available in our Unit in July 2000, and as of December 2001, four of these 17 patients had undergone treatment with liver dialysis. RESULTS: Mean age was 29 years (range: 14-47) and 76% were women. Four of 17 patients underwent a total of 12 (range: 1-4) LDU sessions. Ammonia level tended to be lower following the LDU and all four patients recovered without a need for orthotopic liver transplantation (OLT). Prior to July 2000, eight of 13 patients survived with supportive therapy, three expired and two underwent OLT. No major bleeding episodes were observed during the LDU course. A significant difference was found between the three cases who died and the cases that survived with respect to the grade of encephalopathy (p<0.001). There was significant difference in the admission serum creatinine among survivors (p<0.05). CONCLUSION:
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Authors | Meral Akdoğan, Karim El-Sahwi, Urooj Ahmed, Samy Rashwan, Anthony Sebastian, Harlan Wright, Bakr Nour, Ahmet Gürakar |
Journal | The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
(Turk J Gastroenterol)
Vol. 14
Issue 3
Pg. 164-7
(Sep 2003)
ISSN: 1300-4948 [Print] Turkey |
PMID | 14655058
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Acetaminophen
(adverse effects, therapeutic use)
- Adolescent
- Adult
- Female
- Follow-Up Studies
- Humans
- Liver Failure
(chemically induced, mortality, therapy)
- Liver Function Tests
- Male
- Middle Aged
- Peritoneal Dialysis
(methods)
- Probability
- Retrospective Studies
- Risk Assessment
- Sampling Studies
- Severity of Illness Index
- Survival Analysis
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