Abstract | OBJECTIVE: METHODS AND RESULTS: The patients with essential hypertension (EH) ( n = 30) received a series of normal salt diet (12 g salt/day) for 3 days, low salt diet (2 g salt/day) for 7 days, and high salt diet (20-23 g salt/day) for 7 days. Normotensive control subjects (n = 27) received normal and low salt diets. The plasma level of coupling factor 6, measured by radioimmunoassay, during normal salt diet was higher in patients with EH than in normotensive subjects (17.6 +/- 1.7 versus 12.8 +/- 0.5 ng/ml, P < 0.01). Whereas the plasma level of coupling factor 6 was unchanged after salt restriction in normotensive subjects, it was decreased after salt restriction (from 12 g/day to 2 g/day) and was increased after salt loading (from 2 g/day to 20-23 g/day) in patients with EH. This increase in plasma level of coupling factor 6 was abolished by oral administration of ascorbic acid, but the level of blood pressure was unaffected. The percentage changes in plasma coupling factor 6 level after salt restriction and loading were positively correlated with those in mean blood pressure (r = 0.57, P < 0.01), and negatively correlated with those in plasma nitric oxide level (r = -0.51, P < 0.05). CONCLUSION:
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Authors | Tomohiro Osanai, Satoko Sasaki, Takaatsu Kamada, Naoto Fujiwara, Takao Nakano, Hirofumi Tomita, Toshiro Matsunaga, Koji Magota, Ken Okumura |
Journal | Journal of hypertension
(J Hypertens)
Vol. 21
Issue 12
Pg. 2323-8
(Dec 2003)
ISSN: 0263-6352 [Print] England |
PMID | 14654753
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antioxidants
- Biomarkers
- Nitrates
- Nitrites
- Oxidative Phosphorylation Coupling Factors
- Reactive Oxygen Species
- Sodium, Dietary
- 8-epi-prostaglandin F2alpha
- Dinoprost
- Renin
- F(6) ATPase
- Mitochondrial Proton-Translocating ATPases
- Ascorbic Acid
- Norepinephrine
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Topics |
- Antioxidants
(administration & dosage)
- Ascorbic Acid
(administration & dosage)
- Biomarkers
(blood)
- Blood Pressure
(drug effects)
- Diet, Sodium-Restricted
- Dinoprost
(analogs & derivatives, blood)
- Endothelial Cells
(drug effects, metabolism)
- Female
- Humans
- Hypertension
(blood, physiopathology)
- Male
- Middle Aged
- Mitochondrial Proton-Translocating ATPases
(blood, drug effects)
- Nitrates
(blood)
- Nitrites
(blood)
- Norepinephrine
(blood)
- Oxidative Phosphorylation Coupling Factors
(blood, drug effects)
- Reactive Oxygen Species
(metabolism)
- Renin
(metabolism)
- Sodium, Dietary
(administration & dosage)
- Statistics as Topic
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