Abstract | BACKGROUND: METHODS: Participants were parents or guardians of children 4 to 6 years old immunized at public health clinics across British Columbia, Canada. This included 398 children receiving the fifth consecutive dose of an aP combination vaccine and 402 receiving the fifth dose in a mixed series consisting of at least 1 prior dose of whole-cell pertussis combination vaccine with the remainder as aP combination vaccine. A cross-sectional telephone survey evaluated the extent of local reactions 48 to 96 hours after immunization by asking participants to compare the size of redness and swelling with familiar household items such as Oreo cookies or coins. Associated discomfort and impact on recreational activities, health care utilization, parental time off work, and attitudes toward immunization were also assessed. RESULTS: Children who received the fifth consecutive dose of an aP combination vaccine more often experienced redness (24%) or swelling (16%) the size of an Oreo cookie or larger (>or=46 mm) than children given a mixed series (10% and 9%, respectively) but less often experienced tenderness or limitation of movement at the injection site. Related health care utilization was low. There was no discernible effect on participation in recreational activities or parental attitudes toward vaccine; 90% would recommend the same vaccine to others with children of the same age. CONCLUSIONS:
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Authors | Danuta M Skowronski, Valencia P Remple, Jane Macnabb, Karen Pielak, David M Patrick, Scott A Halperin, David Scheifele |
Journal | Pediatrics
(Pediatrics)
Vol. 112
Issue 6 Pt 1
Pg. e453
(Dec 2003)
ISSN: 1098-4275 [Electronic] United States |
PMID | 14654644
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Pertussis Vaccine
- Vaccines, Acellular
- Vaccines, Combined
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Topics |
- Attitude
- Child
- Child, Preschool
- Cross-Sectional Studies
- Humans
- Immunization, Secondary
(adverse effects)
- Pertussis Vaccine
(adverse effects)
- Vaccination
(psychology)
- Vaccines, Acellular
(adverse effects)
- Vaccines, Combined
(adverse effects)
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