Facilitating effect of histamine on spatial memory deficits induced by dizocilpine as evaluated by 8-arm radial maze in SD rats.

Abstract

AIM:

To investigate whether or not histamine is involved in spatial memory deficits induced by dizocilpine (MK-801) as evaluated by 8-arm radial maze of rats.

METHODS:

8-Arm (4-arm baited) radial maze was used to measure spatial memory in rats.

RESULTS:

Bilaterally intrahippocampal (ih) injection of MK-801 (0.3 microg/site) impaired working memory and reference memory in rats. Both histamine (50, 100 ng/site, ih) and intraperitoneal (ip) injection of histidine (100, 200 mg/kg) markedly improved the spatial memory deficits induced by MK-801. On the other hand, the ameliorating effect of histidine (100 mg/kg, ip) was completely antagonized by alpha-fluoromethylhistidine (alpha-FMH, 5 microg/site, ih), a potent and selective histidine decarboxylase (HDC) inhibitor, and H1-antagonist pyrilamine (1 microg/site, ih), but not by H2-antagonist cimetidine, even at a high dose (2.5 microg/site, ih).

CONCLUSION:

The hippocampal histamine plays an important role in the ameliorating effect on MK-801-induced spatial memory deficits, and its action is mediated through postsynaptic H1-receptor.

• Authors: Yu-Wen Huang, Zhong Chen, Wei-Wei Hu, Li-San Zhang, Wei Wu, Li-Yang Ying, Er-Qing Wei
• Journal: Acta pharmacologica Sinica (Acta Pharmacol Sin) Vol. 24 Issue 12 Pg. 1270-6 (Dec 2003) ISSN: 1671-4083 [Print] United States
• PMID: 14653956 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Histidine
• Dizocilpine Maleate
• Histamine

Topics

• Animals
• Disease Models, Animal
• Dizocilpine Maleate
• Histamine (pharmacology, therapeutic use)
• Histidine (pharmacology)
• Injections, Intraventricular
• Male
• Maze Learning (drug effects)
• Memory Disorders (chemically induced, drug therapy, physiopathology)
• Rats
• Rats, Sprague-Dawley